Autonomous agents powered by large language models introduce a class of execution-layer vulnerabilities -- prompt injection, retrieval poisoning, and uncontrolled tool invocation -- that existing guardrails fail to address systematically. In this work, we propose the Layered Governance Architecture (LGA), a four-layer framework comprising execution sandboxing (L1), intent verification (L2), zero-trust inter-agent authorization (L3), and immutable audit logging (L4). To evaluate LGA, we construct a bilingual benchmark (Chinese original, English via machine translation) of 1,081 tool-call samples -- covering prompt injection, RAG poisoning, and malicious skill plugins -- and apply it to OpenClaw, a representative open-source agent framework. Experimental results on Layer 2 intent verification with four local LLM judges (Qwen3.5-4B, Llama-3.1-8B, Qwen3.5-9B, Qwen2.5-14B) and one cloud judge (GPT-4o-mini) show that all five LLM judges intercept 93.0-98.5% of TC1/TC2 malicious tool calls, while lightweight NLI baselines remain below 10%. TC3 (malicious skill plugins) proves harder at 75-94% IR among judges with meaningful precision-recall balance, motivating complementary enforcement at Layers 1 and 3. Qwen2.5-14B achieves the best local balance (98% IR, approximately 10-20% FPR); a two-stage cascade (Qwen3.5-9B->GPT-4o-mini) achieves 91.9-92.6% IR with 1.9-6.7% FPR; a fully local cascade (Qwen3.5-9B->Qwen2.5-14B) achieves 94.7-95.6% IR with 6.0-9.7% FPR for data-sovereign deployments. An end-to-end pipeline evaluation (n=100) demonstrates that all four layers operate in concert with 96% IR and a total P50 latency of approximately 980 ms, of which the non-judge layers contribute only approximately 18 ms. Generalization to the external InjecAgent benchmark yields 99-100% interception, confirming robustness beyond our synthetic data.

Image generative models are known to duplicate images from the training data as part of their outputs, which can lead to privacy concerns when used for medical image generation. We propose a calibrated per-sample metric for detecting memorization and duplication of training data. Our metric uses image features extracted using an MRI foundation model, aggregates multi-layer whitened nearest-neighbor similarities, and maps them to a bounded \emph{Overfit/Novelty Index} (ONI) and \emph{Memorization Index} (MI) scores. Across three MRI datasets with controlled duplication percentages and typical image augmentations, our metric robustly detects duplication and provides more consistent metric values across datasets. At the sample level, our metric achieves near-perfect detection of duplicates.

Quantum machine learning (QML) is a promising paradigm for tackling computational problems that challenge classical AI. Yet, the inherent probabilistic behavior of quantum mechanics, device noise in NISQ hardware, and hybrid quantum-classical execution pipelines introduce new risks that prevent reliable deployment of QML in real-world, safety-critical settings. This research offers a broad roadmap for Trustworthy Quantum Machine Learning (TQML), integrating three foundational pillars of reliability: (i) uncertainty quantification for calibrated and risk-aware decision making, (ii) adversarial robustness against classical and quantum-native threat models, and (iii) privacy preservation in distributed and delegated quantum learning scenarios. We formalize quantum-specific trust metrics grounded in quantum information theory, including a variance-based decomposition of predictive uncertainty, trace-distance-bounded robustness, and differential privacy for hybrid learning channels. To demonstrate feasibility on current NISQ devices, we validate a unified trust assessment pipeline on parameterized quantum classifiers, uncovering correlations between uncertainty and prediction risk, an asymmetry in attack vulnerability between classical and quantum state perturbations, and privacy-utility trade-offs driven by shot noise and quantum channel noise. This roadmap seeks to define trustworthiness as a first-class design objective for quantum AI.

Reliable uncertainty quantification remains a major obstacle to the deployment of deep learning models under distributional shift. Existing post-hoc approaches that retrofit pretrained models either inherit misplaced confidence or merely reshape predictions, without teaching the model when to be uncertain. We introduce GUIDE, a lightweight evidential learning meta-model approach that attaches to a frozen deep learning model and explicitly learns how and when to be uncertain. GUIDE identifies salient internal features via a calibration stage, and then employs these features to construct a noise-driven curriculum that teaches the model how and when to express uncertainty. GUIDE requires no retraining, no architectural modifications, and no manual intermediate-layer selection to the base deep learning model, thus ensuring broad applicability and minimal user intervention. The resulting model avoids distilling overconfidence from the base model, improves out-of-distribution detection by ~77% and adversarial attack detection by ~80%, while preserving in-distribution performance. Across diverse benchmarks, GUIDE consistently outperforms state-of-the-art approaches, evidencing the need for actively guiding uncertainty to close the gap between predictive confidence and reliability.