Large language models (LLMs) deployed behind APIs and retrieval-augmented generation (RAG) stacks are vulnerable to prompt injection attacks that may override system policies, subvert intended behavior, and induce unsafe outputs. Existing defenses often treat prompts as flat strings and rely on ad hoc filtering or static jailbreak detection. This paper proposes Prompt Control-Flow Integrity (PCFI), a priority-aware runtime defense that models each request as a structured composition of system, developer, user, and retrieved-document segments. PCFI applies a three-stage middleware pipeline, lexical heuristics, role-switch detection, and hierarchical policy enforcement, before forwarding requests to the backend LLM. We implement PCFI as a FastAPI-based gateway for deployed LLM APIs and evaluate it on a custom benchmark of synthetic and semi-realistic prompt-injection workloads. On the evaluated benchmark suite, PCFI intercepts all attack-labeled requests, maintains a 0% False Positive Rate, and introduces a median processing overhead of only 0.04 ms. These results suggest that provenance- and priority-aware prompt enforcement is a practical and lightweight defense for deployed LLM systems.

Prompt injection attacks represent a major vulnerability in Large Language Model (LLM) deployments, where malicious instructions embedded in user inputs can override system prompts and induce unintended behaviors. This paper presents a novel multi-agent defense framework that employs specialized LLM agents in coordinated pipelines to detect and neutralize prompt injection attacks in real-time. We evaluate our approach using two distinct architectures: a sequential chain-of-agents pipeline and a hierarchical coordinator-based system. Our comprehensive evaluation on 55 unique prompt injection attacks, grouped into 8 categories and totaling 400 attack instances across two LLM platforms (ChatGLM and Llama2), demonstrates significant security improvements. Without defense mechanisms, baseline Attack Success Rates (ASR) reached 30% for ChatGLM and 20% for Llama2. Our multi-agent pipeline achieved 100% mitigation, reducing ASR to 0% across all tested scenarios. The framework demonstrates robustness across multiple attack categories including direct overrides, code execution attempts, data exfiltration, and obfuscation techniques, while maintaining system functionality for legitimate queries.