Real-world backdoor attacks often require poisoned datasets to be stored and transmitted before being used to compromise deep learning systems. However, in the era of big data, the inevitable use of lossy compression poses a fundamental challenge to invisible backdoor attacks. We find that triggers embedded in RGB images often become ineffective after the images are lossily compressed into binary bitstreams (e.g., JPEG files) for storage and transmission. As a result, the poisoned data lose its malicious effect after compression, causing backdoor injection to fail. In this paper, we highlight the necessity of explicitly accounting for the lossy compression process in backdoor attacks. This requires attackers to ensure that the transmitted binary bitstreams preserve malicious trigger information, so that effective triggers can be recovered in the decompressed data. Building on the region-of-interest (ROI) coding mechanism in image compression, we propose two poisoning strategies tailored to inevitable lossy compression. First, we introduce Universal Attack Activation, a universal method that uses sample-specific ROI masks to reactivate trigger information in binary bitstreams for learned image compression (LIC). Second, we present Compression-Adapted Attack, a new attack strategy that employs customized ROI masks to encode trigger information into binary bitstreams and is applicable to both traditional codecs and LIC. Extensive experiments demonstrate the effectiveness of both strategies.