Shuaibo Li

The rapid advancement of generative AI in medical imaging has introduced both significant opportunities and serious challenges, especially the risk that fake medical images could undermine healthcare systems. These synthetic images pose serious risks, such as diagnostic deception, financial fraud, and misinformation. However, research on medical forensics to counter these threats remains limited, and there is a critical lack of comprehensive datasets specifically tailored for this field. Additionally, existing media forensic methods, which are primarily designed for natural or facial images, are inadequate for capturing the distinct characteristics and subtle artifacts of AI-generated medical images. To tackle these challenges, we introduce \textbf{MedForensics}, a large-scale medical forensics dataset encompassing six medical modalities and twelve state-of-the-art medical generative models. We also propose \textbf{DSKI}, a novel \textbf{D}ual-\textbf{S}tage \textbf{K}nowledge \textbf{I}nfusing detector that constructs a vision-language feature space tailored for the detection of AI-generated medical images. DSKI comprises two core components: 1) a cross-domain fine-trace adapter (CDFA) for extracting subtle forgery clues from both spatial and noise domains during training, and 2) a medical forensic retrieval module (MFRM) that boosts detection accuracy through few-shot retrieval during testing. Experimental results demonstrate that DSKI significantly outperforms both existing methods and human experts, achieving superior accuracy across multiple medical modalities.

The rapid progress of generative models has made synthetic image detection an increasingly critical task. Most existing approaches attempt to construct a single, universal discriminative space to separate real from fake content. However, such unified spaces tend to be complex and brittle, often struggling to generalize to unseen generative patterns. In this work, we propose TrueMoE, a novel dual-routing Mixture-of-Discriminative-Experts framework that reformulates the detection task as a collaborative inference across multiple specialized and lightweight discriminative subspaces. At the core of TrueMoE is a Discriminative Expert Array (DEA) organized along complementary axes of manifold structure and perceptual granularity, enabling diverse forgery cues to be captured across subspaces. A dual-routing mechanism, comprising a granularity-aware sparse router and a manifold-aware dense router, adaptively assigns input images to the most relevant experts. Extensive experiments across a wide spectrum of generative models demonstrate that TrueMoE achieves superior generalization and robustness.