Chi Liu

The integration of AI with medical images enables the extraction of implicit image-derived biomarkers for a precise health assessment. Recently, retinal age, a biomarker predicted from fundus images, is a proven predictor of systemic disease risks, behavioral patterns, aging trajectory and even mortality. However, the capability to infer such sensitive biometric data raises significant privacy risks, where unauthorized use of fundus images could lead to bioinformation leakage, breaching individual privacy. In response, we formulate a new research problem of biometric privacy associated with medical images and propose RetinaGuard, a novel privacy-enhancing framework that employs a feature-level generative adversarial masking mechanism to obscure retinal age while preserving image visual quality and disease diagnostic utility. The framework further utilizes a novel multiple-to-one knowledge distillation strategy incorporating a retinal foundation model and diverse surrogate age encoders to enable a universal defense against black-box age prediction models. Comprehensive evaluations confirm that RetinaGuard successfully obfuscates retinal age prediction with minimal impact on image quality and pathological feature representation. RetinaGuard is also flexible for extension to other medical image derived biomarkers. RetinaGuard is also flexible for extension to other medical image biomarkers.

AI generative models leave implicit traces in their generated images, which are commonly referred to as model fingerprints and are exploited for source attribution. Prior methods rely on model-specific cues or synthesis artifacts, yielding limited fingerprints that may generalize poorly across different generative models. We argue that a complete model fingerprint should reflect the causality between image provenance and model traces, a direction largely unexplored. To this end, we conceptualize the \emph{causal fingerprint} of generative models, and propose a causality-decoupling framework that disentangles it from image-specific content and style in a semantic-invariant latent space derived from pre-trained diffusion reconstruction residual. We further enhance fingerprint granularity with diverse feature representations. We validate causality by assessing attribution performance across representative GANs and diffusion models and by achieving source anonymization using counterfactual examples generated from causal fingerprints. Experiments show our approach outperforms existing methods in model attribution, indicating strong potential for forgery detection, model copyright tracing, and identity protection.

Transfer learning is devised to leverage knowledge from pre-trained models to solve new tasks with limited data and computational resources. Meanwhile, dataset distillation has emerged to synthesize a compact dataset that preserves critical information from the original large dataset. Therefore, a combination of transfer learning and dataset distillation offers promising performance in evaluations. However, a non-negligible security threat remains undiscovered in transfer learning using synthetic datasets generated by dataset distillation methods, where an adversary can perform a model hijacking attack with only a few poisoned samples in the synthetic dataset. To reveal this threat, we propose Osmosis Distillation (OD) attack, a novel model hijacking strategy that targets deep learning models using the fewest samples. Comprehensive evaluations on various datasets demonstrate that the OD attack attains high attack success rates in hidden tasks while preserving high model utility in original tasks. Furthermore, the distilled osmosis set enables model hijacking across diverse model architectures, allowing model hijacking in transfer learning with considerable attack performance and model utility. We argue that awareness of using third-party synthetic datasets in transfer learning must be raised.